Biochem/physiol Actions

Primary TargetProtein kinase c-Raf

Reversible: yes

Product competes with ATP.

Target IC₅₀: 70 nM against protein kinase c-Raf

Cell permeable: yes

General description

A potent, cell-permeable, reversible, ATP-competitive and specific inhibitor of the protein kinase c-Raf (IC₅₀ = 70 nM). Inhibits c-Raf with ten-fold increased potency compared to B-Raf, but does not inhibit many other protein kinases (even at 50 µM) with the exception of SAPK2a/p38α (IC₅₀ = 2 µM) and SAPK2b/p38β2 (IC₅₀ = 2 µM). The inhibition of c-Raf by ZM 336372 is competitive with respect to ATP.

A potent, cell-permeable, reversible, ATP-competitive and specific inhibitor of c-Raf (IC₅₀ = 70 nM). Inhibits c-Raf with ten-fold greater potency compared to B-Raf. Has no significant effect on many other protein kinases tested (even at 50 µM) with the exception of SAPK2a/p38α (IC₅₀ = 2 µM) and SAPK2b/p38β2 (IC₅₀ = 2 µM).

Legal Information

Sold under license of PCT Application W098/22,103.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Hall-Jackson, C.A., et al. 1999. Chem. Biol.6, 559.

Packaging

1 mg in Plastic ampoule

Packaged under inert gas

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)